Tumor Microenvironment

Intratumoral immunotherapy using a TLR2/3 agonist, L-pampo, induces robust antitumor immune responses and enhances immune checkpoint blockade
Won Suk Lee, Dong Sung Kim, Jeong Hun Kim, Yoonki Heo, Hannah Yang, Eun-Jin Go, Jin Hyoung Kim, Seung Joon Lee, Byung Cheol Ahn, Jung Sun Yum, Hong Jae Chon, Chan Kim

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004799; DOI: 10.1136/jitc-2022-004799
Immune suppressive microenvironment in liver metastases contributes to organ-specific response of immunotherapy in advanced non-small cell lung cancer
Jia-Yi Deng, Qing Gou, Lingling Yang, Zhi-Hong Chen, Ming-Yi Yang, Xiao-Rong Yang, Hong-Hong Yan, Xue-Wu Wei, Jia-Qi Liu, Jian Su, Wen-Zhao Zhong, Chong-Rui Xu, Yi-Long Wu, Qing Zhou

Journal for ImmunoTherapy of Cancer Jul 2023, 11 (7) e007218; DOI: 10.1136/jitc-2023-007218
Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment
Michael Chiorazzi, Jan Martinek, Bradley Krasnick, Yunjiang Zheng, Keenan J Robbins, Rihao Qu, Gabriel Kaufmann, Zachary Skidmore, Melani Juric, Laura A Henze, Frederic Brösecke, Adam Adonyi, Jun Zhao, Liang Shan, Esen Sefik, Jacqueline Mudd, Ye Bi, S Peter Goedegebuure, Malachi Griffith, Obi Griffith, Abimbola Oyedeji, Sofia Fertuzinhos, Rolando Garcia-Milian, Daniel Boffa, Frank Detterbeck, Andrew Dhanasopon, Justin Blasberg, Benjamin Judson, Scott Gettinger, Katerina Politi, Yuval Kluger, Karolina Palucka, Ryan C Fields, Richard A Flavell

Journal for ImmunoTherapy of Cancer Jul 2023, 11 (7) e006921; DOI: 10.1136/jitc-2023-006921
NKG2A⁺CD8⁺ T cells infiltration determines immunosuppressive contexture and inferior response to immunotherapy in clear cell renal cell carcinoma
Youqi Qiu, Li Liu, Wenbin Jiang, Ziyang Xu, Jiahao Wang, Siyuan Dai, Jianming Guo, Jiejie Xu

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e008368; DOI: 10.1136/jitc-2023-008368
Comparative analysis of immune infiltrates in head and neck cancers across anatomical sites
Tara Muijlwijk, Dennis N L M Nijenhuis, Sonja H Ganzevles, Arjen Brink, Changlin Ke, Joseph N Fass, Venkatesh Rajamanickam, C René Leemans, Yoshinobu Koguchi, Bernard A Fox, Jos B Poell, Ruud H Brakenhoff, Rieneke van de Ven

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e007573; DOI: 10.1136/jitc-2023-007573
Cell membrane-anchored and tumor-targeted IL-12 T-cell therapy destroys cancer-associated fibroblasts and disrupts extracellular matrix in heterogenous osteosarcoma xenograft models
Jiemiao Hu, Alexander J Lazar, Davis Ingram, Wei-Lien Wang, Wendong Zhang, Zhiliang Jia, Dristhi Ragoonanan, Jian Wang, Xueqing Xia, Kris Mahadeo, Richard Gorlick, Shulin Li

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e006991; DOI: 10.1136/jitc-2023-006991
Multiomics profiling reveals the benefits of gamma-delta (γδ) T lymphocytes for improving the tumor microenvironment, immunotherapy efficacy and prognosis in cervical cancer
Junyi Li, Yuanjie Cao, Yancheng Liu, Lu Yu, Zhen Zhang, Xiaofeng Wang, Hui Bai, Yuhan Zhang, Shaochuan Liu, Miaomiao Gao, Chenglu Lu, Chen Li, Yong Guan, Zhen Tao, Zhiqiang Wu, Jie Chen, Zhiyong Yuan

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e008355; DOI: 10.1136/jitc-2023-008355
Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy
Natalie K. Horvat, Isaac Karpovsky, Maggie Phillips, Megan M. Wyatt, Margaret A. Hall, Cameron J. Herting, Jacklyn Hammons, Zaid Mahdi, Richard A. Moffitt, Chrystal M. Paulos, Gregory B. Lesinski

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e008086; DOI: 10.1136/jitc-2023-008086
Historical perspective and future directions: computational science in immuno-oncology
Cora A Ricker, Kevin Meli, Eliezer M Van Allen

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e008306; DOI: 10.1136/jitc-2023-008306
VB-111 (ofranergene obadenovec) in combination with nivolumab in patients with microsatellite stable colorectal liver metastases: a single center, single arm, phase II trial
Kelley Coffman-D'Annibale, Yuta Myojin, Cecilia Monge, Changqing Xie, Donna Mabry Hrones, Bradford J Wood, Elliot B Levy, David Kleiner, William Douglas Figg, Seth M Steinberg, Bernadette Redd, Tim F Greten

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e008079; DOI: 10.1136/jitc-2023-008079

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