Tumor Microenvironment

Blood-based extracellular matrix biomarkers are correlated with clinical outcome after PD-1 inhibition in patients with metastatic melanoma
Daan P Hurkmans, Christina Jensen, Stijn L W Koolen, Joachim Aerts, Morten Asser Karsdal, Ron H J Mathijssen, Nicholas Willumsen

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001193; DOI: 10.1136/jitc-2020-001193
Deep immunophenotyping at the single-cell level identifies a combination of anti-IL-17 and checkpoint blockade as an effective treatment in a preclinical model of data-guided personalized immunotherapy
Koji Nagaoka, Masataka Shirai, Kiyomi Taniguchi, Akihiro Hosoi, Changbo Sun, Yukari Kobayashi, Kazuhiro Maejima, Masashi Fujita, Hidewaki Nakagawa, Sachiyo Nomura, Kazuhiro Kakimi

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001358; DOI: 10.1136/jitc-2020-001358
Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy
Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Ruben L van den Oever, Jim Middelburg, Dana A M Mustafa, Rob C Hoeben, Sjoerd H van der Burg, Thorbald van Hall, Nadine van Montfoort

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001191; DOI: 10.1136/jitc-2020-001191
Galectin-9-based immune risk score model helps to predict relapse in stage I–III small cell lung cancer
Peixin Chen, Liping Zhang, Wei Zhang, Chenglong Sun, Chunyan Wu, Yayi He, Caicun Zhou

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001391; DOI: 10.1136/jitc-2020-001391
Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions
Jules Russick, Pierre-Emmanuel Joubert, Mélanie Gillard-Bocquet, Carine Torset, Maxime Meylan, Florent Petitprez, Marie-Agnes Dragon-Durey, Solenne Marmier, Aditi Varthaman, Nathalie Josseaume, Claire Germain, Jérémy Goc, Marie-Caroline Dieu-Nosjean, Pierre Validire, Ludovic Fournel, Laurence Zitvogel, Gabriela Bindea, Audrey Lupo, Diane Damotte, Marco Alifano, Isabelle Cremer

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001054; DOI: 10.1136/jitc-2020-001054
Infiltrating pattern and prognostic value of tertiary lymphoid structures in resected non-functional pancreatic neuroendocrine tumors
Wu-Hu Zhang, Wen-Quan Wang, Xuan Han, He-Li Gao, Shuai-Shuai Xu, Shuo Li, Tian-Jiao Li, Hua-Xiang Xu, Hao Li, Long-Yun Ye, Xuan Lin, Chun-Tao Wu, Jiang Long, Xian-Jun Yu, Liang Liu

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001188; DOI: 10.1136/jitc-2020-001188
Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapy
Xuanwen Bao, Hangyu Zhang, Wei Wu, Shaobing Cheng, Xiaomeng Dai, Xudong Zhu, Qihan Fu, Zhou Tong, Lulu Liu, Yi Zheng, Peng Zhao, Weijia Fang, Fanglong Liu

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001437; DOI: 10.1136/jitc-2020-001437
2,5-dimethylcelecoxib improves immune microenvironment of hepatocellular carcinoma by promoting ubiquitination of HBx-induced PD-L1
Zhanfei Chen, Yiyin Chen, Lirong Peng, Xiaoqian Wang, Nanhong Tang

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001377; DOI: 10.1136/jitc-2020-001377
Combining IL-2-based immunotherapy with commensal probiotics produces enhanced antitumor immune response and tumor clearance
Linlin Shi, Jianyong Sheng, Guozhong Chen, Peng Zhu, Changping Shi, Bei Li, Chaiwoo Park, Jingyi Wang, Bixiang Zhang, Zhi Liu, Xiangliang Yang

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e000973; DOI: 10.1136/jitc-2020-000973
Improving the therapeutic index in adoptive cell therapy: key factors that impact efficacy
Ena Wang, Alessandra Cesano, Lisa H Butterfield, Francesco Marincola

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001619; DOI: 10.1136/jitc-2020-001619

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