Tumor Microenvironment

2,5-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis
Banglun Pan, Zhanfei Chen, Xiaoxia Zhang, Zengbin Wang, Yuxin Yao, Xiaoxuan Wu, Jiacheng Qiu, Hua Lin, Liumin Yu, Haijian Tu, Nanhong Tang

Journal for ImmunoTherapy of Cancer Jun 2023, 11 (6) e006817; DOI: 10.1136/jitc-2023-006817
Developing a definition of immune exclusion in cancer: results of a modified Delphi workshop
Guy Travis Clifton, Mace Rothenberg, Paolo Antonio Ascierto, Glenn Begley, Michael Cecchini, Joseph Paul Eder, Francois Ghiringhelli, Antoine Italiano, Marina Kochetkova, Rong Li, Fatima Mechta-Grigoriou, Sara I Pai, Paolo Provenzano, Ellen Puré, Antoni Ribas, Kurt A Schalper, Wolf Herve Fridman

Journal for ImmunoTherapy of Cancer Jun 2023, 11 (6) e006773; DOI: 10.1136/jitc-2023-006773
Intralesional administration of VAX014 facilitates in situ immunization and potentiates immune checkpoint blockade in immunologically cold tumors
Katherine A Reil, Shingo Tsuji, Elsa Molina, Kinsey L Nelson, Kathleen L McGuire, Matthew J Giacalone

Journal for ImmunoTherapy of Cancer Jun 2023, 11 (6) e006749; DOI: 10.1136/jitc-2023-006749
Robust IL-2-dependent antitumor immunotherapy requires targeting the high-affinity IL-2R on tumor-specific CD8⁺ T cells
Kathryn M LaPorte, Rosmely Hernandez, Alicia Santos Savio, Thomas R Malek

Journal for ImmunoTherapy of Cancer Jun 2023, 11 (6) e006611; DOI: 10.1136/jitc-2022-006611
Prognostic value of von Willebrand factor levels in patients with metastatic melanoma treated by immune checkpoint inhibitors
Julia-Christina Stadler, Laura Keller, Christian Mess, Alexander T Bauer, Julian Koett, Glenn Geidel, Isabel Heidrich, Sabine Vidal-y-Sy, Antje Andreas, Carlotta Stramaglia, Mark Sementsov, Wiebcke Haberstroh, Benjamin Deitert, Inka Lilott Hoehne, Robin Reschke, Thomas Haalck, Klaus Pantel, Christoffer Gebhardt, Stefan W Schneider

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006456; DOI: 10.1136/jitc-2022-006456
Dendritic cell therapy augments antitumor immunity triggered by CDK4/6 inhibition and immune checkpoint blockade by unleashing systemic CD4 T-cell responses
Amrendra Kumar, Vijay Ramani, Vijaya Bharti, Daniel de Lima Bellan, Nabil Saleh, Roman Uzhachenko, Chengli Shen, Carlos Arteaga, Ann Richmond, Sangeetha M Reddy, Anna Vilgelm

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006019; DOI: 10.1136/jitc-2022-006019
Emerging organoid-immune co-culture models for cancer research: from oncoimmunology to personalized immunotherapies
Luc Magré, Monique M A Verstegen, Sonja Buschow, Luc J W van der Laan, Maikel Peppelenbosch, Jyaysi Desai

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006290; DOI: 10.1136/jitc-2022-006290
The NR_109/FUBP1/c-Myc axis regulates TAM polarization and remodels the tumor microenvironment to promote cancer development
Cong Zhang, Sisi Wei, Suli Dai, Xiaoya Li, Huixia Wang, Hongtao Zhang, Guogui Sun, Baoen Shan, Lianmei Zhao

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006230; DOI: 10.1136/jitc-2022-006230
Combining histological grade, TILs, and the PD-1/PD-L1 pathway to identify immunogenic tumors and de-escalate radiotherapy in early breast cancer: a secondary analysis of a randomized clinical trial
Axel Stenmark Tullberg, Martin Sjöström, Lena Tran, Emma Niméus, Fredrika Killander, Anikó Kovács, Dan Lundstedt, Erik Holmberg, Per Karlsson

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006618; DOI: 10.1136/jitc-2022-006618
Nasal administration of recombinant Neospora caninum secreting IL-15/IL-15Rα inhibits metastatic melanoma development in lung
Arthur Battistoni, Louis Lantier, Anne di Tommaso, Céline Ducournau, Laurie Lajoie, Mahtab Samimi, Loïs Coënon, Clément Rivière, Mathieu Epardaud, Leslie Hertereau, Agathe Poupée-Beaugé, Juliette Rieu, Marie-Noëlle Mévélec, Gordon Scott Lee, Nathalie Moiré, Stephanie Germon, Isabelle Dimier-Poisson

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006683; DOI: 10.1136/jitc-2023-006683

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