Tumor Microenvironment

Neoadjuvant nivolumab plus ipilimumab in resectable non-small cell lung cancer
Joshua E Reuss, Valsamo Anagnostou, Tricia R Cottrell, Kellie N Smith, Franco Verde, Marianna Zahurak, Mara Lanis, Joseph C Murray, Hok Yee Chan, Caroline McCarthy, Daphne Wang, James R White, Stephen Yang, Richard Battafarano, Stephen Broderick, Errol Bush, Malcolm Brock, Jinny Ha, David Jones, Taha Merghoub, Janis Taube, Victor E Velculescu, Gary Rosner, Peter Illei, Drew M Pardoll, Suzanne Topalian, Jarushka Naidoo, Ben Levy, Matthew D Hellmann, Julie R Brahmer, Jamie E Chaft, Patrick M Forde

Journal for ImmunoTherapy of Cancer Sep 2020, 8 (2) e001282; DOI: 10.1136/jitc-2020-001282
Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy
Elham Beyranvand Nejad, Camilla Labrie, Ziena Abdulrahman, Marit J van Elsas, Eva Rademaker, Jan Willem Kleinovink, Tetje C van der Sluis, Suzanne van Duikeren, Amina F A.S Teunisse, Aart G Jochemsen, Jan Oosting, Noel F C C de Miranda, Thorbald Van Hall, Ramon Arens, Sjoerd H van der Burg

Journal for ImmunoTherapy of Cancer Sep 2020, 8 (2) e001326; DOI: 10.1136/jitc-2020-001326
Bone marrow MSC from pediatric patients with B-ALL highly immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity
Samanta Romina Zanetti, Paola Alejandra Romecin, Meritxell Vinyoles, Manel Juan, José Luis Fuster, Mireia Cámos, Sergi Querol, Mario Delgado, Pablo Menendez

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e001419; DOI: 10.1136/jitc-2020-001419
HITM-SURE: Hepatic immunotherapy for metastases phase Ib anti-CEA CAR-T study utilizing pressure enabled drug delivery
Steven C Katz, Ashley E Moody, Prajna Guha, John C Hardaway, Ethan Prince, Jason LaPorte, Mirela Stancu, Jill E Slansky, Kimberly R Jordan, Richard D Schulick, Robert Knight, Abdul Saied, Vincent Armenio, Richard P Junghans

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e001097; DOI: 10.1136/jitc-2020-001097
An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy
Hui Wang, Qian Xu, Chanyuan Zhao, Ziqi Zhu, Xiaoqing Zhu, Junjie Zhou, Shuming Zhang, Tiqun Yang, Biying Zhang, Jun Li, Meiling Yan, Renming Liu, Changchun Ma, Yan Quan, Yongqu Zhang, Weifeng Zhang, Yiqun Geng, Chuangzhen Chen, Shaobin Chen, Ditian Liu, Yuping Chen, Dongping Tian, Min Su, Xueling Chen, Jiang Gu

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000661; DOI: 10.1136/jitc-2020-000661
M2-like macrophages dictate clinically relevant immunosuppression in metastatic ovarian cancer
Michal Hensler, Lenka Kasikova, Karel Fiser, Jana Rakova, Petr Skapa, Jan Laco, Tereza Lanickova, Ladislav Pecen, Iva Truxova, Sarka Vosahlikova, Irena Moserova, Ivan Praznovec, Vit Drochytek, Martina Rehackova, Tomas Brtnicky, Lukas Rob, Vladimir Benes, Jelena Pistolic, Ludek Sojka, Ales Ryska, Catherine Sautes-Fridman, Wolf Herve Fridman, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000979; DOI: 10.1136/jitc-2020-000979
Short-course radiotherapy promotes pro-inflammatory macrophages via extracellular vesicles in human rectal cancer
Victoria Stary, Brigitte Wolf, Daniela Unterleuthner, Julia List, Merjem Talic, Johannes Laengle, Andrea Beer, Johanna Strobl, Georg Stary, Helmut Dolznig, Michael Bergmann

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000667; DOI: 10.1136/jitc-2020-000667
Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation
Bogang Wu, Huai-Chin Chiang, Xiujie Sun, Bin Yuan, Payal Mitra, Yanfen Hu, Tyler J Curiel, Rong Li

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000964; DOI: 10.1136/jitc-2020-000964
Remodeling tumor immune microenvironment (TIME) for glioma therapy using multi-targeting liposomal codelivery
Zening Zheng, Jiaxin Zhang, Jizong Jiang, Yang He, Wenyuan Zhang, Xiaopeng Mo, Xuejia Kang, Qin Xu, Bing Wang, Yongzhuo Huang

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000207; DOI: 10.1136/jitc-2019-000207
Intratumoral TIGIT⁺ CD8⁺ T-cell infiltration determines poor prognosis and immune evasion in patients with muscle-invasive bladder cancer
Zhaopei Liu, Quan Zhou, Zewei Wang, Hongyu Zhang, Han Zeng, Qiuren Huang, Yifan Chen, Wenbin Jiang, Zhiyuan Lin, Yang Qu, Ying Xiong, Qi Bai, Yu Xia, Yiwei Wang, Li Liu, Yu Zhu, Le Xu, Bo Dai, Jianming Guo, Jiajun Wang, Yuan Chang, Weijuan Zhang

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000978; DOI: 10.1136/jitc-2020-000978

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