Tumor Microenvironment

Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma
Nicholas H Chakiryan, Youngchul Kim, Anders Berglund, Andrew Chang, Gregory J Kimmel, Ali Hajiran, Jonathan Nguyen, Carlos Moran-Segura, Daryoush Saeed-Vafa, Esther N Katende, Neale Lopez-Blanco, Jad Chahoud, Phillip Rappold, Philippe E Spiess, Michelle Fournier, Daniel Jeong, Liang Wang, Jamie K Teer, Jasreman Dhillon, Fengshen Kuo, Abraham Ari Hakimi, Philipp M Altrock, James J Mulé, Brandon J Manley

Journal for ImmunoTherapy of Cancer Apr 2023, 11 (4) e006195; DOI: 10.1136/jitc-2022-006195
Vector Aided Microenvironment programming (VAMP): reprogramming the TME with MVA virus expressing IL-12 for effective antitumor activity
Laura Seclì, Luigia Infante, Linda Nocchi, Maria De Lucia, Gabriella Cotugno, Guido Leoni, Elisa Micarelli, Irene Garzia, Lidia Avalle, Giulia Sdruscia, Fulvia Troise, Simona Allocca, Giuseppina Romano, Elisa Scarselli, Anna Morena D'Alise

Journal for ImmunoTherapy of Cancer Apr 2023, 11 (4) e006718; DOI: 10.1136/jitc-2023-006718
Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer
Noor Shakfa, Deyang Li, Gwenaelle Conseil, Elizabeth D Lightbody, Juliette Wilson-Sanchez, Ali Hamade, Stephen Chenard, Natasha A. Jawa, Brian J. Laight, Afrakoma Afriyie-Asante, Kathrin Tyryshkin, Martin Koebel, Madhuri Koti

Journal for ImmunoTherapy of Cancer Apr 2023, 11 (4) e006170; DOI: 10.1136/jitc-2022-006170
Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer
Miao He, Qihua He, Xiuyu Cai, Jun Liu, Hongshen Deng, Feng Li, Ran Zhong, Yi Lu, Haoxin Peng, Xiangrong Wu, Zisheng Chen, Shen Lao, Caichen Li, Jianfu Li, Jianxing He, Wenhua Liang

Journal for ImmunoTherapy of Cancer Apr 2023, 11 (4) e005539; DOI: 10.1136/jitc-2022-005539
Barriers to immune cell infiltration in tumors
Marit M Melssen, Natasha D Sheybani, Katie M Leick, Craig L Slingluff

Journal for ImmunoTherapy of Cancer Apr 2023, 11 (4) e006401; DOI: 10.1136/jitc-2022-006401
Irreversible electroporation augments β-glucan induced trained innate immunity for the treatment of pancreatic ductal adenocarcinoma
Matthew R Woeste, Rejeena Shrestha, Anne E Geller, Shu Li, Diego Montoya-Durango, Chuanlin Ding, Xiaoling Hu, Hong Li, Aaron Puckett, Robert A Mitchell, Traci Hayat, Min Tan, Yan Li, Kelly M McMasters, Robert C G Martin, Jun Yan

Journal for ImmunoTherapy of Cancer Apr 2023, 11 (4) e006221; DOI: 10.1136/jitc-2022-006221
Tumor and immune remodeling following radiotherapy in human renal cell carcinoma
Jacky Chow, Adil Khan, Madeline Gaudieri, Brianna J Wasik, Alexis Conway, Kah Teong Soh, Elizabeth A Repasky, Thomas Schwaab, Paul K Wallace, Scott I Abrams, Anurag K Singh, Jason B Muhitch

Journal for ImmunoTherapy of Cancer Apr 2023, 11 (4) e006392; DOI: 10.1136/jitc-2022-006392
Dissecting tumor lymphocyte infiltration to predict benefit from immune-checkpoint inhibitors in metastatic colorectal cancer: lessons from the AtezoT RIBE study
Roberto Moretto, Daniele Rossini, Aurélie Catteau, Carlotta Antoniotti, Mirella Giordano, Alessandra Boccaccino, Clara Ugolini, Agnese Proietti, Veronica Conca, Alboukadel Kassambara, Filippo Pietrantonio, Lisa Salvatore, Sara Lonardi, Stefano Tamberi, Emiliano Tamburini, Anello Marcello Poma, Jacques Fieschi, Gabriella Fontanini, Gianluca Masi, Jérôme Galon, Chiara Cremolini

Journal for ImmunoTherapy of Cancer Apr 2023, 11 (4) e006633; DOI: 10.1136/jitc-2022-006633
High tumor mutational burden predicts favorable response to anti-PD-(L)1 therapy in patients with solid tumor: a real-world pan-tumor analysis
Jaeyun Jung, You Jeong Heo, Sehhoon Park

Journal for ImmunoTherapy of Cancer Apr 2023, 11 (4) e006454; DOI: 10.1136/jitc-2022-006454
YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6
Saisai Chen, Kai Lu, Yue Hou, Zonghao You, Chuanjun Shu, Xiaoying Wei, Tiange Wu, Naipeng Shi, Guangyuan Zhang, Jianping Wu, Shuqiu Chen, Lihua Zhang, Wenchao Li, Dingxiao Zhang, Shenghong Ju, Ming Chen, Bin Xu

Journal for ImmunoTherapy of Cancer Apr 2023, 11 (4) e006020; DOI: 10.1136/jitc-2022-006020

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