Tumor Microenvironment

Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination
Peter M Carlson, Ravi B Patel, Jen Birstler, Matthew Rodriquez, Claire Sun, Amy K Erbe, Amber M Bates, Ian Marsh, Joseph Grudzinski, Reinier Hernandez, Alexander A Pieper, Arika S Feils, Alexander L Rakhmilevich, Jamey P Weichert, Bryan P Bednarz, Paul M Sondel, Zachary S Morris

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e005463; DOI: 10.1136/jitc-2022-005463
Novel combination strategy of high intensity focused ultrasound (HIFU) and checkpoint blockade boosted by bioinspired and oxygen-supplied nanoprobe for multimodal imaging-guided cancer therapy
Rui Tang, Hongye He, Xiaohong Lin, Nianhong Wu, Li Wan, Qiaoqi Chen, Yaqin Hu, Chen Cheng, Yuting Cao, Xun Guo, Ying Zhou, Xialin Xiong, Min Zheng, Qi Wang, Faqi Li, Yang Zhou, Pan Li

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e006226; DOI: 10.1136/jitc-2022-006226
Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma
Mary K McKenna, Ada Ozcan, Daniel Brenner, Norihiro Watanabe, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, Challice Bonifant, David M Markovitz, Malcolm K Brenner

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e005891; DOI: 10.1136/jitc-2022-005891
TYRO3 blockade enhances anti-PD-1 therapy response by modulating expression of CCN1 in tumor microenvironment
Miso Park, Da-Sol Kuen, Jaewoo Park, Munkyung Choi, Yeonji Kim, Eun Chae Roh, Yong June Choi, Yoon Gyoon Kim, Yeonseok Chung, Sung Yun Cho, Keon Wook Kang

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e006084; DOI: 10.1136/jitc-2022-006084
Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma
Meenal Sinha, Courtney Betts, Li Zhang, Madeline J Griffith, Isabelle Solman, Brandon Chen, Eric Liu, Whitney Tamaki, Jacob Stultz, Jaqueline Marquez, Shamilene Sivagnanam, Alexander Cheung, Denise Pener, Anne Fahlman, Erin Taber, Kimberly Lerner, Matthew Crocker, Kendra Todd, Brindha Rajagopalan, Clarisha Ware, Mark Bridge, Johnson Vo, Hannah Dragomanovich, Julie Sudduth-Klinger, Gina Vaccaro, Charles D Lopez, Margaret Tempero, Lisa M Coussens, Lawrence Fong

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e005425; DOI: 10.1136/jitc-2022-005425
Molecular underpinnings of exceptional response in primary malignant melanoma of the esophagus to anti-PD-1 monotherapy
Jie Dai, Xue Bai, Xuan Gao, Lirui Tang, Yu Chen, Linzi Sun, Xiaoting Wei, Caili Li, Zhonghui Qi, Yan Kong, Chuanliang Cui, Zhihong Chi, Xinan Sheng, Zelong Xu, Bin Lian, Siming Li, Xieqiao Yan, Bixia Tang, Li Zhou, Xuan Wang, Xuefeng Xia, Jun Guo, Lili Mao, Lu Si

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e005937; DOI: 10.1136/jitc-2022-005937
T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins
Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e005714; DOI: 10.1136/jitc-2022-005714
Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy
Xia Liu, Fusheng Si, David Bagley, Feiya Ma, Yuanqin Zhang, Yan Tao, Emily Shaw, Guangyong Peng

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e005020; DOI: 10.1136/jitc-2022-005020
Mast cell-T cell axis alters development of colitis-dependent and colitis-independent colorectal tumours: potential for therapeutically targeting via mast cell inhibition
Juliana Y Sakita, Jefferson Elias-Oliveira, Daniela Carlos, Emerson de Souza Santos, Luciana Yamamoto Almeida, Tathiane M Malta, Mariângela O Brunaldi, Sergio Albuquerque, Cleide Lúcia Araújo Silva, Marcus V Andrade, Vania L D Bonato, Sergio Britto Garcia, Fernando Queiroz Cunha, Guilherme Cesar Martelossi Cebinelli, Ronaldo B Martins, Jason Matthews, Leandro Colli, Francis L Martin, Sergio A Uyemura, Vinicius Kannen

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e004653; DOI: 10.1136/jitc-2022-004653
Tumor microenvironment shows an immunological abscopal effect in patients with NSCLC treated with pembrolizumab-radiotherapy combination
Lieke L van der Woude, Mark A J Gorris, Inge M N Wortel, Jeroen H A Creemers, Kiek Verrijp, Kim Monkhorst, Katrien Grünberg, Michel M van den Heuvel, Johannes Textor, Carl G Figdor, Berber Piet, Willemijn S M E Theelen, I Jolanda M de Vries

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e005248; DOI: 10.1136/jitc-2022-005248

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