Tumors

Differential quantities of immune checkpoint-expressing CD8 T cells in soft tissue sarcoma subtypes
Yarne Klaver, Maud Rijnders, Astrid Oostvogels, Rebecca Wijers, Marcel Smid, Dirk Grünhagen, Cornelis Verhoef, Stefan Sleijfer, Cor Lamers, Reno Debets

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000271; DOI: 10.1136/jitc-2019-000271
Small molecule AZD4635 inhibitor of A_2AR signaling rescues immune cell function including CD103⁺ dendritic cells enhancing anti-tumor immunity
Alexandra Borodovsky, Christine M Barbon, Yanjun Wang, Minwei Ye, Laura Prickett, Dinesh Chandra, Joseph Shaw, Nanhua Deng, Kris Sachsenmeier, James D Clarke, Bolan Linghu, Giles A Brown, James Brown, Miles Congreve, Robert KY Cheng, Andrew S Dore, Edward Hurrell, Wenlin Shao, Richard Woessner, Corinne Reimer, Lisa Drew, Stephen Fawell, Alwin G Schuller, Deanna A Mele

Journal for ImmunoTherapy of Cancer Jul 2020, 8 (2) e000417; DOI: 10.1136/jitc-2019-000417
Interrogating the immune-modulating roles of radiation therapy for a rational combination with immune-checkpoint inhibitors in treating pancreatic cancer
Kenji Fujiwara, May Tun Saung, Hao Jing, Brian Herbst, MacKenzie Zarecki, Stephen Muth, Annie Wu, Elaine Bigelow, Linda Chen, Keyu Li, Neolle Jurcak, Alex B Blair, Ding Ding, Michael Wichroski, Jordan Blum, Nathan Cheadle, Jennifer Koenitzer, Lei Zheng

Journal for ImmunoTherapy of Cancer Jul 2020, 8 (2) e000351; DOI: 10.1136/jitc-2019-000351
Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer
Marta Trüb, Franziska Uhlenbrock, Christina Claus, Petra Herzig, Martin Thelen, Vaios Karanikas, Marina Bacac, Maria Amann, Rosemarie Albrecht, Claudia Ferrara-Koller, Daniela Thommen, Sacha Rothschield, Spasenija Savic Prince, Kirsten D Mertz, Gieri Cathomas, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Christian Klein, Heinz Laubli, Abhishek S Kashyap, Alfred Zippelius

Journal for ImmunoTherapy of Cancer Jul 2020, 8 (2) e000238; DOI: 10.1136/jitc-2019-000238

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