ReviewGDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant?☆
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2023, Critical Reviews in Oncology/HematologyLong-term exposure to GDNF induces dephosphorylation of Ret, AKT, and ERK1/2, and is ineffective at protecting midbrain dopaminergic neurons in cellular models of Parkinson's disease
2022, Molecular and Cellular NeuroscienceCitation Excerpt :Since then, it has also been found in the adult brain and different neuronal populations during development (Lin et al., 1993; Choi-Lundberg and Bohn, 1995). Many studies have suggested that GDNF acts as a potent neurotrophic factor, promoting survival in different neuronal populations such as spinal motor neurons, central noradrenergic neurons, or sympathetic neurons, among others (Trupp et al., 1995; Airaksinen et al., 1999; Airaksinen and Saarma, 2002). Likewise, GDNF acts as a powerful trophic factor favoring, not only the survival and plasticity, but also the proliferation, differentiation, and protection of dopaminergic (DAergic) neurons, as well as the synthesis of dopamine (DA) and DAergic transmission in the developing and adult brain (Lin et al., 1993; Strömberg et al., 1993; Tomac et al., 1995; Bourque and Trudeau, 2000; Kordower et al., 2000; Kirik et al., 2004; Kramer and Liss, 2015; Gantner et al., 2020).
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All three authors contributed equally.
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To whom correspondence should be addressed. E-mail: saarma@ operoni.helsinki.fi.