Regular PaperGene fusions encoding chimaeric transcription factors in solid tumours
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The role of SYT-SSX fusion gene in tumorigenesis of synovial sarcoma
2021, Pathology Research and PracticeCitation Excerpt :The metastasis-free survival in patients with SYT-SSX1 is worse than that in patients with SYT-SSX2, and the prognosis of patients with SYT-SSX2 is better than that of patients with SYT-SSX1 [10]. SYT-SSX gene fusion is considered an important early event in the development of SS [11,12], and it may even be the initial event. SYT-SSX fusion protein plays the role of transcriptional regulation and can regulate the expression of downstream genes [13,14].
Management of Bone Tumours in Paediatric Oncology
2013, Clinical OncologyCitation Excerpt :The most common gene rearrangement is the t(11;22)(q24;q12) translocation, found in about 85% of these tumours [7,8]. Other variant translocations have been described where EWS is fused with ERG t(21;22)(q22;q12) [9], ETV1 (t(7;22)(p22;q12)) [9], E1AF (t(17;22)(q21;q12)) [10] and FEV (t(2;22)(q33;q12)) [11] in addition to more complex translocations involving multiple chromosomes such as t(11;14;22)(q24;q11;q12) and t(10;11;22)(p11.2;q24;q12). The biological importance of these more complex gene rearrangements is not yet clear.
Molecular diagnosis in ewing family tumors the rizzoli experience-222 consecutive cases in four years
2011, Journal of Molecular DiagnosticsCitation Excerpt :Molecular diagnosis, using either FISH to detect the gene rearrangement and RT-PCR to detect the fusion transcript, is now a routine part of the pathological examination of EFT38 and has allowed for more precise diagnoses. In the present study, we reviewed the available scientific data3,4,7,11,12,15,16,18,24–26,33–35,39–56 to collect the most prevalent chimeric types found for EFT to date (Figures 5, 6, 7, and 8). We also report the experience of the Department of Pathology at the Rizzoli Institute from 2006 to 2009.
Homeobox Genes
2011, Fetal and Neonatal Physiology E-Book, Fourth EditionEwing's Sarcoma
2009, Oncology of Infancy and Childhood: Expert Consult - Online and PrintETV6-NTRK3: A chimeric protein tyrosine kinase with transformation activity in multiple cell lineages
2005, Seminars in Cancer Biology