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Memory T Cells pp 79–95Cite as

CD8 T-Cell Memory Differentiation during Acute and Chronic Viral Infections

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 684))

Abstract

CD8 T-cell responses play an important role in protection against intracellular pathogens. Memory CD8 T cells mediate rapid clearance of pathogens upon secondary infection owing to their elevated frequency, ready localization to peripheral sites of infection and their ability to rapidly expand and mount effector functions. Such potent long-lasting protective memory CD8 T cells develop in acute infections where antigen is effectively cleared. In contrast, chronic infections with persistently high viral loads are characterized by CD8 T-cell dysfunction. In this chapter we present our current understanding of signals and mechanisms that regulate the development of functional long-lived memory CD8 T cells during acute infections. This is discussed in the context of proposed models of memory differentiation and compared with CD8 T-cell exhaustion and altered T-cell homeostasis, as occurs during persistent viral infections.

These authors contributed equally.

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Authors and Affiliations

  1. Emory Vaccine Center, Emory, University School of Medicine, Atlanta, Georgia, 30322, USA

    Vandana Kalia, Surojit Sarkar & Rafi Ahmed

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  1. Vandana Kalia
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  2. Surojit Sarkar
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  3. Rafi Ahmed
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Correspondence to Rafi Ahmed .

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Editors and Affiliations

  1. The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, La Jolla, California, USA

    Maurizio Zanetti MD (Professor of Medicine) (Professor of Medicine)

  2. Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA

    Stephen P. Schoenberger PhD (member in the Laboratory of Cellular Immunology) (member in the Laboratory of Cellular Immunology)

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© 2010 Landes Bioscience and Springer Science+Business Media

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Kalia, V., Sarkar, S., Ahmed, R. (2010). CD8 T-Cell Memory Differentiation during Acute and Chronic Viral Infections. In: Zanetti, M., Schoenberger, S.P. (eds) Memory T Cells. Advances in Experimental Medicine and Biology, vol 684. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6451-9_7

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