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Dual biological effects of the cytokines interleukin-10 and interferon-γ

  • Opinion Paper
  • Published:
Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

Abstract

It is generally thought that each cytokine exerts either immune stimulatory (inflammatory) or immune inhibitory (antiinflammatory or regulatory) biological activities. However, multiple cytokines can enact both inhibitory and stimulatory effects on the immune system. Two of these cytokines are interleukin (IL)-10 and interferon-gamma (IFNγ). IL-10 has demonstrated antitumor immunity even though it has been known for years as an immunoregulatory protein. Generally perceived as an immune stimulatory cytokine, IFNγ can also induce inhibitory molecule expression including B7-H1 (PD-L1), indoleamine 2,3-dioxygenase (IDO), and arginase on multiple cell populations (dendritic cells, tumor cells, and vascular endothelial cells). In this review, we will summarize current knowledge of the dual roles of both of these cytokines and stress the previously underappreciated stimulatory role of IL-10 and inhibitory role of IFNγ in the context of malignancy. Our progressive understanding of the dual effects of these cytokines is important for dissecting cytokine-associated pathology and provides new avenues for developing effective immune therapy against human diseases, including cancer.

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Acknowledgments

This work was supported in part by research grants from the NIH/NCI R01 grants and the Ovarian Cancer Research Foundation (WZ) and the NIH through the University of Michigan’s Cancer Center Support Grant (P30CA46592).

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Surgery, University of Michigan School of Medicine, C560B MSRB II/Box 0669, 1150 W. Medical Center Drive, Ann Arbor, MI, 48109-0669, USA

    Cailin Moira Wilke, Shuang Wei, Lin Wang, Ilona Kryczek & Weiping Zou

  2. Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA

    Cailin Moira Wilke & Weiping Zou

  3. Central Laboratory, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China

    Lin Wang

  4. Department of Medicine, University of Michigan, Ann Arbor, MI, USA

    John Kao

  5. University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA

    John Kao & Weiping Zou

  6. Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA

    Weiping Zou

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  1. Cailin Moira Wilke
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  2. Shuang Wei
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Correspondence to Weiping Zou.

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Wilke, C.M., Wei, S., Wang, L. et al. Dual biological effects of the cytokines interleukin-10 and interferon-γ. Cancer Immunol Immunother 60, 1529–1541 (2011). https://doi.org/10.1007/s00262-011-1104-5

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