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Impact of the treatment-free interval on health-related quality of life in patients with multiple myeloma: a UK cross-sectional survey

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Abstract

Background

While the impact of various treatments on myeloma patients’ health-related quality of life (HRQL) has been reported, the impact of a treatment-free interval (TFI) is currently unclear. The aims of this study were to assess if (1) a TFI is associated with a better HRQL vs. other treatment phases and (2) the length of the TFI influences HRQL.

Methods

A cross-sectional postal survey was conducted in the UK. The survey was sent to 605 multiple myeloma patients via the charity Myeloma UK and asked patients to rate their HRQL using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30), EORTC QLQ-MY20 and the EQ-5D. The results were analysed using ordinary least squares regression.

Results

Surveys of 402 (67 %) were returned; 370 (61 %) were considered eligible for analysis. Results demonstrated that being in a first TFI relative to other treatment phases and experiencing a longer TFI were significantly associated with better HRQL as assessed by various domains of the QLQ-C30, MY20 and EQ-5D.

Conclusion

Patients enjoy better HRQL when in their first TFI, and the length of the TFI also positively impacts on HRQL This information may be important for patients and their physicians making treatment decisions and has implications for treatment protocols incorporating extended therapy.

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Acknowledgments

The authors would like to thank Myeloma UK for their assistance in this study and all patients that participated.

Conflict of interest

This study and manuscript were sponsored by Janssen-Cilag Ltd., where the author Sabine Gaugris is an employee. All primary data is available for review if requested.

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Authors and Affiliations

  1. Oxford Outcomes Ltd., 188 Embarcadero, Suite 200, San Francisco, CA, 94105, USA

    S. Acaster

  2. Janssen-Cilag Ltd., High Wycombe, Bucks, HP12 4EG, UK

    S. Gaugris

  3. St. James’s Institute of Oncology, University of Leeds, Leeds, LS9 7TF, UK

    G. Velikova

  4. University College Hospital, London, NW1 2BU, UK

    K. Yong

  5. Oxford Outcomes Ltd., Oxford, OX2 0JJ, UK

    A. J. Lloyd

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  1. S. Acaster
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  5. A. J. Lloyd
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Corresponding author

Correspondence to S. Acaster.

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Acaster, S., Gaugris, S., Velikova, G. et al. Impact of the treatment-free interval on health-related quality of life in patients with multiple myeloma: a UK cross-sectional survey. Support Care Cancer 21, 599–607 (2013). https://doi.org/10.1007/s00520-012-1548-y

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  • DOI: https://doi.org/10.1007/s00520-012-1548-y

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