Abstract
Purpose
The plasma D-dimer (D-dimer) level, a marker of hypercoagulation, has been reported to be associated with survival in several types of cancers. This retrospective study was conducted to evaluate the prognostic significance of the preoperative D-dimer level in patients with completely resected non-small cell lung cancer (NSCLC).
Methods
A total of 237 completely resected NSCLC patients were included in this study. In addition to age, sex, the smoking status, etc., the association between the preoperative D-dimer level and survival was explored.
Results
The patients were divided into three groups according to the D-dimer level: group A (≤0.50 μg/ml, n = 76), group B (0.51–0.86 μg/ml, n = 79) and group C (>0.86 μg/ml, n = 82). The 5-year overall survival rate was 89.6 % (95 % confidence interval (CI) 77.7–95.3) for group A, 75.1 % (95 % CI 62.3–83.6) for group B and 60.1 % (95 % CI 46.8–71.1) for group C (P trend <0.001). A multivariate survival analysis showed that the D-dimer level (group B vs. group A HR 4.25, group C vs. group A HR 4.11) was an independent significant prognostic factor, in addition to age, sex, the pathological stage and the serum carcinoembryonic antigen level.
Conclusions
The preoperative D-dimer level is an independent prognostic factor in patients with completely resected NSCLC.
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Acknowledgments
We are grateful to Dr. Keitaro Matsuo, Department of Preventive Medicine, Kyushu University Faculty of Medical Science, for his advice and review of the statistical analysis.
Funding
This study was supported in part by a grant from takeda Science Foundation.
Conflicts of interest
None of the authors has any conflict of interest to declare in association with this study.
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Fukumoto, K., Taniguchi, T., Usami, N. et al. The preoperative plasma D-dimer level is an independent prognostic factor in patients with completely resected non-small cell lung cancer. Surg Today 45, 63–67 (2015). https://doi.org/10.1007/s00595-014-0894-4
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DOI: https://doi.org/10.1007/s00595-014-0894-4