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Role of interleukin-10 in breast cancer

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Abstract

Cytokines are low molecular weight regulatory proteins or glycoprotein that modulates the intensity and duration of immune response by stimulating or inhibiting the activation, proliferation, and/or differentiation of target cells. Different cytokines are known to have diverse role in breast cancer initiation and progression. Interleukin-10 (IL-10), a pleiotropic anti-inflammatory cytokine, induces immunosuppression and assists in escape from tumor immune surveillance. Like several other cytokines, IL-10 also can exert dual proliferative and inhibitory effect on breast tumor cells indicating a complex role of IL-10 in breast cancer initiation and progression. In this review, we tried to put together a comprehensive current view on significance of IL-10 in promotion, inhibition, and importance as prognosticator in breast cancer based on in vitro, in vivo, and clinical evidences. For literature collection, we conducted PubMed search with keywords “IL-10” and “breast cancer”.

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Acknowledgments

The authors are thankful to Indian Council of Medical Research (ICMR), Govt. of India for financial support by (Grant Number 5/13/12/2007-NCDIII). Hamidullah would like to thank Department of Biotechnology (DBT), Govt. of India for Junior Research Fellowship. CDRI communication number of this manuscript is 8143.

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None of the authors have any conflict of interest.

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Correspondence to Rituraj Konwar.

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Hamidullah, Changkija, B. & Konwar, R. Role of interleukin-10 in breast cancer. Breast Cancer Res Treat 133, 11–21 (2012). https://doi.org/10.1007/s10549-011-1855-x

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