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Antibody-based imaging strategies for cancer

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Abstract

Although mainly developed for preclinical research and therapeutic use, antibodies have high antigen specificity, which can be used as a courier to selectively deliver a diagnostic probe or therapeutic agent to cancer. It is generally accepted that the optimal antigen for imaging will depend on both the expression in the tumor relative to normal tissue and the homogeneity of expression throughout the tumor mass and between patients. For the purpose of diagnostic imaging, novel antibodies can be developed to target antigens for disease detection, or current FDA-approved antibodies can be repurposed with the covalent addition of an imaging probe. Reuse of therapeutic antibodies for diagnostic purposes reduces translational costs since the safety profile of the antibody is well defined and the agent is already available under conditions suitable for human use. In this review, we will explore a wide range of antibodies and imaging modalities that are being translated to the clinic for cancer identification and surgical treatment.

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Authors and Affiliations

  1. Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA

    Jason M. Warram, Esther de Boer, Thomas K. Chung & Eben L. Rosenthal

  2. Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA

    Hyunki Kim

  3. Department of Radiology & Radiological Sciences, Vanderbilt University, Nashville, TN, USA

    Anna G. Sorace

  4. Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Rick G. Pleijhuis & Gooitzen M. van Dam

  5. Division of Otolaryngology, BDB Suite 563, 1808 7th Avenue South, Birmingham, AL, 35294-0012, USA

    Eben L. Rosenthal

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Warram, J.M., de Boer, E., Sorace, A.G. et al. Antibody-based imaging strategies for cancer. Cancer Metastasis Rev 33, 809–822 (2014). https://doi.org/10.1007/s10555-014-9505-5

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