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PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment

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Abstract

Anti-cancer cancer-targeted therapies are designed to exploit a particular vulnerability in the tumor, which in most cases results from its dependence on an oncogene and/or loss of a tumor suppressor. Mutations in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway are freqcuently found in breast cancers and associated with cellular transformation, tumorigenesis, cancer progression, and drug resistance. Several drugs targeting PI3K/ATK/mTOR are currently in clinical trials, mainly in combination with endocrine therapy and anti-HER2 therapy. These drugs are the focus of this review.

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  1. Departments of Medicine and Cancer Biology; Breast Cancer Program, Vanderbilt-Ingram, Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA

    Angel Guerrero-Zotano, Ingrid A. Mayer & Carlos L. Arteaga

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  1. Angel Guerrero-Zotano
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  2. Ingrid A. Mayer
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  3. Carlos L. Arteaga
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Correspondence to Carlos L. Arteaga.

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Guerrero-Zotano, A., Mayer, I.A. & Arteaga, C.L. PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment. Cancer Metastasis Rev 35, 515–524 (2016). https://doi.org/10.1007/s10555-016-9637-x

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  • DOI: https://doi.org/10.1007/s10555-016-9637-x

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