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Kidney injuries related to ipilimumab

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Summary

Monoclonal antibodies directed against the immune checkpoint protein cytotoxic T-lymphocyte antigen-4 (CTLA-4; CD152) have been investigated in metastatic melanoma and other cancers and have shown promising results. Inhibition of CTLA-4 characteristically induces well-known side effects called “immune-related adverse events” (irAEs). IrAEs mainly include colitis, dermatitis, hepatitis, endocrinopathies; uveitis, iridocyclitis, neuropathies, and inflammatory myopathy have occasionally been reported. Kidney involvement is rare. We report 2 cases of acute granulomatous interstitial nephritis and present, based on literature review, renal disorders related to Ipilimumab therapy. Autoimmune symptoms have to be carefully checked for patients treated with CTLA-4 inhibitors. In order to reduce the risk of sequelae, early recognition of irAEs and treatment initiation are crucial.

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The authors declare no financial conflict of interest.

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Authors and Affiliations

  1. Department of Nephrology, Pitie-Salpetriere, 47-80 Boulevard de l’Hôpital, 75013, Paris, France

    Hassane Izzedine, Victor Gueutin, Chems Gharbi & Alain Baumelou

  2. Department of Pathology, Pitie Salpetriere Hospital, Paris, France

    Philippe Rouvier

  3. Department of Dermatology and INSERM Unit U 981, Gustave Roussy Institute, Villejuif, Paris-Sud, France

    Christine Mateus, Caroline Robert, Emilie Routier & Marina Thomas

Authors
  1. Hassane Izzedine
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  2. Victor Gueutin
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  3. Chems Gharbi
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  4. Christine Mateus
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  5. Caroline Robert
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  7. Marina Thomas
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  8. Alain Baumelou
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  9. Philippe Rouvier
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Correspondence to Hassane Izzedine.

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Izzedine, H., Gueutin, V., Gharbi, C. et al. Kidney injuries related to ipilimumab. Invest New Drugs 32, 769–773 (2014). https://doi.org/10.1007/s10637-014-0092-7

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  • DOI: https://doi.org/10.1007/s10637-014-0092-7

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