Summary
Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.
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This work was supported by Grants No. 30330330 and 30421005 from Natural Science Foundation of China.
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Ma, L., Zhao, X. & Zhu, X. Mitosin/CENP-F in mitosis, transcriptional control, and differentiation. J Biomed Sci 13, 205–213 (2006). https://doi.org/10.1007/s11373-005-9057-3
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DOI: https://doi.org/10.1007/s11373-005-9057-3