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Targeting IL-17 in autoimmunity and inflammation

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Abstract

The discovery of two distinct subsets of helper T cells, IFN-γ-producing Th1 cells and IL-4-producing Th2 cells, about three decades ago enabled us to understand the immunopathology of cell-mediated and allergic inflammatory diseases in humans. The observation that T cell-mediated experimental autoimmune diseases can be induced in mice lacking Th1 and Th2 cell responses prompted many immunologists to hypothesize that there might be additional subsets in helper T cell population which mediate autoimmunity in the absence of Th1 and Th2 cells. Consequently, multiple independent research groups identified IL-17-expressing RORγt+CD4+ T cell population as a distinct subset of helper T cells which promotes autoimmune tissue inflammation. Subsequent studies have revealed that innate immune cells, including γδ T cells, NKT cells and innate lymphoid cells, also produce type 17 cytokines and contribute to tissue inflammation. In this review, we discuss our current understanding on the biology of IL-17 and the therapeutic potential of targeting IL-17 for the treatment of immune disorders in humans.

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Acknowledgments

We appreciate Inbo Shim and Da-Sol Kuen for editing manuscript. This work is supported by Grants 2014R1A2A1A11054364 (YC) and 0430-20150023 (Basic Science Research Program) (YJP) from the National Research Foundation of Korea (NRF) Grant funded by the Korean government (MEST).

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    1. Laboratory of Immune Regulation, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea

      Byung-Seok Kim, Young-Jun Park & Yeonseok Chung

    2. BK21 Plus Program, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea

      Byung-Seok Kim & Yeonseok Chung

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    Byung-Seok Kim and Young-Jun Park have equally contributed to this work.

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    Kim, BS., Park, YJ. & Chung, Y. Targeting IL-17 in autoimmunity and inflammation. Arch. Pharm. Res. 39, 1537–1547 (2016). https://doi.org/10.1007/s12272-016-0823-8

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    • DOI: https://doi.org/10.1007/s12272-016-0823-8

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