Fine chemical modifications at N- and C-termini enhance peptide presentation to T cells, by increasing the lifespan of both free and MHC-complexed peptides
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Cited by (27)
Challenge to overcome current limitations of cell-penetrating peptides
2021, Biochimica et Biophysica Acta - Proteins and ProteomicsCitation Excerpt :For example, a tetrapeptide Arg-Leu-Tyr-Glu (RLYE) has a half-life of 1.2 h in serum due to the degradation by aminopeptidase B and N, but N-acetylation can elongate the half-life to 8.8 h [178]. Also, N-acetylation and C-amidation can significantly increase the stability of major histocompatibility complex (MHC)-binding peptides in serum [179,180]. This capping or amidation could simply be accomplished during SPPS of CPPs by performing a final acetylation step and selecting the appropriate resins [181,182].
Cation exchange-HPLC and mass spectrometry reveal C-terminal amidation of an IgG1 heavy chain
2007, Analytical BiochemistryCitation Excerpt :ESI and matrix-assisted laser desorption/ionization (MALDI) MS have shown that the conotoxin TxVIIA is C-terminally amidated [24], and α-amidation has been detected in recombinant peptides by ESI MS [25]. Evidence has also been published showing α-amidation to be a protective PTM against exopeptidase degradation [26,27]. In peptide hormones, amidation has been shown to influence bioactivity through a reduction of the net positive charge of the peptide and a change in its conformation [22].
Cross-presentation of a CMV pp65 epitope by human dendritic cells using bee venom PLA<inf>2</inf> as a membrane-binding vector
2005, FEBS LettersCitation Excerpt :In contrast, the presentation of peptide N9V was not affected by BFA and the level of cell surface HLA-A2 was only slightly reduced. In addition, P30–34 was not presented by DCs fixed with glutaraldehyde, a treatment known to block intracellular processing but not extracellular processing [27], while the peptide was. uP30–34 was not presented by fixed or untreated DCs, showing also the absence of extracellular processing.
Study at the air/water interface of a hepatitis A N-acetylated and C-amidated synthetic peptide (AcVP3(110-121)-NH<inf>2</inf>): I. Surface activity and insertion in lipid monolayers
2001, Journal of Colloid and Interface Science