Cell
Volume 116, Issue 2, 23 January 2004, Pages 299-311
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Review
Unraveling V(D)J Recombination: Insights into Gene Regulation

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Abstract

V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports—the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1.

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