Vitiligo in patients with metastatic melanoma: A good prognostic sign

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Abstract

We have identified and studied twenty-seven patients with melanoma who also had vitiligo Four patients had vitiligo before the diagnosis of melanoma, and twenty-three developed depigmentation after the diagnosis of malignancy We also have reviewed published reports about twenty-four other patients with melanoma who developed vitiligo The clinical course of the melanoma in the fifty-one patients was remarkably similar Thirty-seven had a melanoma arising at a site which tends to carry a poor prognosis, for example, on the trunk, under the nail, or on the mucous membranes Forty-nine patients had metastases in regional lymph nodes or at distal sites Thirty-three patients survived 5 years, and twenty-five survived 10 years These data suggest that the appearance of vitiligo in patients with metastatic melanoma portends a longer survival than expected The patients with vitiligo are not necessarily cured and eventually may succumb to metastatic disease We were unable to determine whether the vitiligo caused retardation of tumor growth or whether the melanoma caused vitiligo

References (31)

  • M Mitchell et al.

    Comparison of cell-mediated immunity to melanoma cells in patients with vitiligo, halo nevi, and melanoma

    J Invest Dermatol

    (1980)
  • K Balabanov et al.

    Malignant melanoma and vitiligo

    Dermatologica

    (1968)
  • Y Cohen et al.

    Vitiligo associated with BCG-methanol extraction residue in malignant melanoma

    Dermatologica

    (1979)
  • E Frenk

    Depigmentations vitiligineuses chez des patients atteints de melanomes malins

    Dermatologica

    (1969)
  • MS Nirankari et al.

    Uveal malignant melanoma with leucoderma

    J All-India Ophthalmol Soc

    (1968)
  • GW Milton et al.

    Malignant melanoma and vitiligo

    Australas J Dermatol

    (1971)
  • RC Donaldson et al.

    Uveitis and vitiligo associated with BCG treatment for malignant melanoma

    Surgery

    (1974)
  • RT Gregor

    Vitiligo and malignant melanoma: A significant association?

    S Afr Med J

    (1976)
  • JP Ortonne et al.

    Giant melanin granules in vit-iliginous achromia with malignant melanoma

    Acta Derm Venereol (Stockh)

    (1978)
  • AJ Sober et al.

    Uveitis, poliosis, hypomelanosis, and alopecia in a patient with malignant melanoma

    Arch Dermatol

    (1978)
  • JP Ortonne et al.

    Depigmentation cutanée associee au melanome malin

    Ann Dermatol Venereol

    (1978)
  • M Takahashi et al.

    Vitiligo-like leukoderma in patients with metastatic malignant melanoma

    Pigment Cell

    (1979)
  • DM Albert et al.

    Vitiligo or halo nevi occurring in two patients with choroidal melanoma

    Arch Dermatol

    (1982)
  • JF Laucius et al.

    Cutaneous depigmentary phenomena in patients with malignant melanoma

  • AW Kopf et al.

    Leukoderma and malignant melanomas

  • Cited by (0)

    Supported in part by funds from the West Haven VA Medical Center National Institutes of Health grant AM 25252 CA 08341 the General Clinical Research Center RR 00125 and the International Union Against Cancer

    1

    From the Department of Dermatology West Haven VA Medical Center West Haven Departments of Medicine and Dermatology Yale University School of Medicine New Haven and the Department of Surgery Sydney Hospital Sydney

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