Original articleGeneral thoracicTNM Stage Is the Most Important Determinant of Survival in Metachronous Lung Cancer
Section snippets
Patients and Methods
The Thoracic Surgery Tumor Registry at the Weill Medical College of Cornell University served as the database. A retrospective review of this prospective database was used to identify patients with surgically resected MLC between 1995 and 2008.
After resection of the index primary cancer, all patients were followed according to our institutional guidelines, which included computed tomographic scans obtained postoperatively at 6 and 12 months, and annually thereafter [4, 5]. Metachronous lung
Results
From 1995 to 2008, 58 patients with surgically resected MLC were identified from a total of 1,900 patients who underwent pulmonary resection for NSCLC (3.1%). The median age at presentation of the MLC was 67 years (range, 48 to 86 years) and 35 of 58 (60%) were women (Table 1).
Comment
Approximately 35,000 patients in the United States undergo surgery for lung cancer each year, predominantly for early stage disease [7]. Historically, patients without lymph node metastases can be expected to have 5-year survival rates from 57% to 67% [1]. Recent reports indicate that 5-year survival for patients with stage IA cancer may even approach 80% [9, 10]. These patients are at significant risk to develop an MLC, with an incidence between 1% and 2% per patient, per year [2]. This risk
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Lobectomy Versus Sublobectomy in Metachronous Second Primary Lung Cancer: A Propensity Score Study
2018, Annals of Thoracic SurgeryCitation Excerpt :The 5-year survival rate of the entire cohort before PSM was 47.5% (48.5% for lobectomy vs 46.2% for sublobectomy), which was mainly consistent with a previous pooled rate of 44% from a meta-analysis [7]. More favorable 5-year survival rates were also reported [17–19]. Patients in our study with stage I MSPLC accounted for approximately 76.7% of the entire cohort.
Surgical therapy for bilateral multiple primary lung cancer
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2015, Annals of Thoracic SurgeryCitation Excerpt :Such patients may have insufficient pulmonary function to undergo an additional lobectomy procedure. Many studies have reported the safety and efficacy of surgical resection for second primary NSCLC [7–37], and some have reported that sublobar resection can result in overall and cancer-specific survival comparable to that with lobectomy [8, 15]. Our meta-analysis also did not demonstrate a significant difference between lobectomy and sublobar resection; however, these results must be tempered by a significant degree of heterogeneity between studies in this subgroup analysis and the relatively small number of patients in both groups.