Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1833, Issue 1, January 2013, Pages 122-139
ReviewProtein tyrosine kinase regulation by ubiquitination: Critical roles of Cbl-family ubiquitin ligases
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Highlights
► Cbl-family ubiquitin ligases function as negative regulators of PTK signaling ► Recruitment and activation mechanisms ensure Cbl selectivity for activated PTKs ► Cbl-dependent ubiquitination regulates PTK degradation in lysosome and proteasome ► Genetic studies demonstrate essential roles of Cbl proteins in physiological pathways ► Mutational inactivation of Cbl is causally linked to human leukemia
Keywords
Cbl
E3 ubiquitin ligase
Tyrosine kinase binding domain
Ubiquitination
Signal transduction
Animal model
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