Cancer Cell
Volume 27, Issue 4, 13 April 2015, Pages 462-472
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Perspective
Macrophages and Therapeutic Resistance in Cancer

https://doi.org/10.1016/j.ccell.2015.02.015Get rights and content
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How neoplastic cells respond to therapy is not solely dependent on the complexity of the genomic aberrations they harbor but is also regulated by numerous dynamic properties of the tumor microenvironment. Identifying and targeting critical pathways that improve therapeutic efficacy by bolstering anti-tumor immune responses holds great potential for improving outcomes and impacting long-term patient survival. Macrophages are key regulators of homeostatic tissue and tumor microenvironments. Therefore, therapeutics impacting macrophage presence and/or bioactivity have shown promise in preclinical models and are now being evaluated in the clinic. This review discusses the molecular/cellular pathways identified so far whereby macrophages mediate therapeutic responses.

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Present address: Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA