Elsevier

Immunobiology

Volume 220, Issue 2, February 2015, Pages 185-192
Immunobiology

Novel insights into the immunomodulatory role of the dendritic cell and macrophage-expressed C-type lectin MGL

https://doi.org/10.1016/j.imbio.2014.10.002Get rights and content
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Abstract

Based on their ability to balance tolerance and inflammation, antigen presenting cells, such as dendritic cells and macrophages contribute to the maintenance of immune homeostasis as well as the instigation of immune activation. Acting as key sensors of tissue integrity and pathogen invasion, they are well equipped with a wide variety of pattern recognition receptors, to which the C-type lectin family also belongs. C-type lectins are glycan-binding receptors that mediate cell–cell communication and pathogen recognition, besides participating in the endocytosis of antigens for presentation to T cells and the fine-tuning of immune responses. Here we review the current state-of-the-art on the dendritic cell and macrophage-expressed C-type lectin macrophage galactose-type lectin (MGL), highlighting the binding specificities, signaling properties and modulation of innate and adaptive immunity by its human and murine orthologues.

Abbreviations

CLR
C-type lectin receptor
DC
dendritic cell
dDC
dermal dendritic cell
GalNAc
N-acetylgalactosamine
KO
knockout
MAG
multiple antigenic peptides
MGL
macrophage galactose-type lectin
OVA
ovalbumin
PSA
prostate-specific antigen

Keywords

Tn antigen
C-type lectin
Dendritic cells
Macrophages
T cells

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