Immunity
Volume 38, Issue 3, 21 March 2013, Pages 596-605
ArticlePersistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype
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Graphical Abstract
Highlights
► The amount of antigen dictates the Tfh cell and germinal center B cell response ► Tfh cell and germinal center B cell numbers are highly interrelated ► Maintenance of Tfh cells requires persistent antigen and germinal center B cells ► Overstimulation of Tfh cells results in dysregulated antibody responses
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Present address: Howard Hughes Medical Institute and Department of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
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