Trends in Immunology
SpotlightTLS in Tumors: What Lies Within
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Cited by (19)
The Unmet Needs of the Diagnosis, Staging, and Treatment of Gastrointestinal Tumors
2020, Seminars in Nuclear MedicineCitation Excerpt :The tumor contains all types of immune cells, including macrophages, dendritic cells, mast cells, natural killer cells, naive lymphocytes and memory lymphocytes, B cells and effector T cells.59 Immune cells may be positioned in the tumor interior, invasive margin or adjacent normal tissue, including tertiary lymphoid structures (TLS).60-66 The location, density, and functional orientation of various immune cell populations (referred to as "immune context" or immunological context.)
Immune-based identification of cancer patients at high risk of progression
2018, Current Opinion in ImmunologyCitation Excerpt :The application of MCP-Counter to transcriptomic TCGA datasets also reveals a generally favorable impact of cytotoxic lymphocytes, whereas fibroblasts are usually related with a poorer survival [23••]. The presence of TLS that delineates generation and maintenance of effector memory T and B cell responses correlates with prolonged survival in most tumor types [34], with the exception of liver cancer where they are associated with higher recurrence rate when present in the cirrhotic tissue surrounding tumor nodules [35,36,37••]. Renal cell carcinoma (RCC) is a group of heterogeneous tumors with distinct genetic abnormalities.
Tumor-associated immune aggregates in oral cancer: Their cellular composition and potential prognostic significance
2017, Medical HypothesesCitation Excerpt :A small scaled study of OSCCs (n = 80) has found that the presence of TaIAs was a positive prognostic factor [11]. However, new evidence has revealed that the composition of these TaIAs has the potential to influence either tumor progression or tumor regression by being either pro-inflammatory (e.g. CD8+ cytotoxic T cells) or immunosuppressive (e.g., regulatory T cells) [8,21–23]. Therefore, in situ investigation of TaIA organization and density may enable the identification of patients with higher risks of recurrence and guide treatment decisions [12,24].
Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy
2023, Frontiers in ImmunologyPhysiology of chemokines in the cancer microenvironment
2023, American Journal of Physiology - Cell Physiology