Original articleIncreased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: A Rochester Epidemiology Project population-based study in Minnesota
Section snippets
Methods
Institutional review board approval was obtained from Mayo Clinic and the Olmsted Medical Center as part of the Rochester Epidemiology Project (REP). REP resources include health care information for Olmsted County, Minnesota, residents from 1966 to the present. The medical records for a given patient are linked together across virtually all Olmsted County health care providers as a part of the REP records linkage system. This allows the health care information for an Olmsted County resident to
Results
We identified a cohort of 717 Olmsted County residents with the diagnosis of NHL established from January 1, 1976, through December 31, 2005. Although these data are from a number of decades ago to 2005, the diagnostic criteria for CLL has remained relatively stable, and the information obtained from the large amount of follow-up years is pertinent. It is possible, however, that the treatment regimens for lymphoma have changed significantly over this large amount of time, which could introduce
Discussion
In the past 30 years, investigators have suggested an increased incidence of solid tumors in the setting of CLL. In particular, the risk is significantly increased for malignant melanoma, soft-tissue sarcomas, and lung cancer.1, 10, 16, 17, 18, 19, 20, 21, 22 In 1 small study, the risk of skin cancer in the setting of CLL increased 8-fold.16 These tumors not only are more common in this clinical setting, but they also may behave more aggressively. Patients with CLL and SCC or BCC were found to
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Supported in part by a Dermatology Foundation Career Development Award for the study of lymphoma-associated skin cancer (Dr Brewer).
Conflicts of interest: None declared.