Elsevier

Journal of Hepatology

Volume 54, Issue 4, April 2011, Pages 830-834
Journal of Hepatology

Clinical Application of Basic Science
Potential of immunotherapy for hepatocellular carcinoma

https://doi.org/10.1016/j.jhep.2010.10.013Get rights and content
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open access

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with limited therapeutic options. Since HCC has been shown to be immunogenic, T cell-based immunotherapy is considered a promising treatment. In this review, we summarize current knowledge of T cell responses against tumour-associated antigens, as well as the mechanisms underlying the poor quality of these responses in patients with HCC. Insights into these important aspects of HCC immunology are crucial for the further development of novel immunotherapies.

Keywords

Hepatocellular carcinoma (HCC)
Tumour antigens
T cell responses
Immune suppressor mechanisms
Immunotherapy

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