Elsevier

Journal of Thoracic Oncology

Volume 11, Issue 12, December 2016, Pages 2238-2240
Journal of Thoracic Oncology

Brief Report
Anti-PD1 Antibody Treatment and the Development of Acute Pulmonary Tuberculosis

https://doi.org/10.1016/j.jtho.2016.07.006Get rights and content
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Abstract

Recently, cancer immunotherapy by immune checkpoint inhibitors has been considered one of the pillars for the treatment of cancer. Nivolumab is the first immune checkpoint inhibitor approved for lung cancer treatment in Japan. Although nivolumab has superior survival benefits and fewer adverse events than cytotoxic agents, it can generate dysimmune toxicities, known as immune-related adverse events. Although autoimmune manifestations are well-known immune-related adverse events, the development of infectious diseases is rare. Here, we report on a patient with advanced NSCLC in whom pulmonary tuberculosis developed rapidly during nivolumab treatment and discuss the potential mechanisms as well as what is known about infections during checkpoint inhibitor therapy.

Keywords

Nivolumab
Immune checkpoint inhibitor
Immunotherapy
Tuberculosis
Opportunistic infection

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Disclosure: The authors declare no conflict of interest.