Molecular Cell
Volume 50, Issue 3, 9 May 2013, Pages 407-419
ArticleInhibition of AMPK Catabolic Action by GSK3
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Graphical Abstract
Highlights
► GSK3 constitutively interacts with the AMPK complex through the β subunit ► GSK3 phosphorylates the α subunit of AMPK and inhibits its kinase activity ► The PI3K-Akt pathway enhances GSK3-dependent phosphorylation of the α subunit ► GSK3-dependent AMPK inhibition is critical for cells to enter an anabolic state
Cited by (0)
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Present address: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
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Present address: Children’s Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
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