Molecular Cell
Volume 54, Issue 4, 22 May 2014, Pages 547-558
Journal home page for Molecular Cell

Review
Principles and Properties of Eukaryotic mRNPs

https://doi.org/10.1016/j.molcel.2014.04.033Get rights and content
Under an Elsevier user license
open archive

The proper processing, export, localization, translation, and degradation of mRNAs are necessary for regulation of gene expression. These processes are controlled by mRNA-specific regulatory proteins, noncoding RNAs, and core machineries common to most mRNAs. These factors bind the mRNA in large complexes known as messenger ribonucleoprotein particles (mRNPs). Herein, we review the components of mRNPs, how they assemble and rearrange, and how mRNP composition differentially affects mRNA biogenesis, function, and degradation. We also describe how properties of the mRNP “interactome” lead to emergent principles affecting the control of gene expression.

Cited by (0)