Associate editor: B. TeicherTargeting the TGFβ pathway for cancer therapy
Under a Creative Commons license
open access
Keywords
Angiogenesis
Fibrosis
Metastasis
Microenvironment
TGFβ inhibitors
Tumor-stroma interactions
Abbreviations
bFGF
basic fibroblast growth factor
bi-shRNAi
bi-functional short hairpin RNAi
CAF
cancer-associated fibroblasts
CR
complete response
CTGF
connective tissue growth factor
ECM
extracellular matrix
EMT
epithelial-to-mesenchymal transition
HCC
hepatocellular carcinoma
HGF
hepatocyte growth factor
HSC
hepatic stellate cell
I-SMAD
inhibitory SMAD
IFN
interferon
IL
interleukin
LOH
loss of heterozygosity
MCP-1
chemoattractant protein-1
MMP
matrix metalloproteinase
MSI
microsatellite instability
NK
natural killer
NOX
NADPH oxidase
NSCLC
non-small cell lung cancer
PBMC
peripheral blood mononuclear cell
PDAC
pancreatic ductal adenocarcinoma
PDGF
platelet-derived growth factor
PR
partial response
PSC
pancreatic stellate cell
OS
overall survival
ROS
reactive oxygen specie
SD
stable disease
TGFβ
transforming growth factor-β
TNFα
tumor necrosis factor-α
Th
T-helper
T-reg
T-regulatory cell
VEGF
vascular endothelial growth factor
Cited by (0)
Copyright © 2014 The Authors. Published by Elsevier Inc.