Abstract
SPECIFIC acquired immunity to Schistosoma mansoni in the mouse has only recently been demonstrated definitively1. This phenomenon does not occur until 12 weeks after primary infection and has been found to be adoptively transferred only by serum2. The induction of so-called ‘immunity’ to S. mansoni has also been reported in mice and hamsters exposed to a wide variety of unrelated organisms and extracts3–6, but in most, if not all cases it is likely to be nonspecific. Although all of these acquired forms of resistance have been lumped together under the name of immunity, it is probable that the mechanisms of specific and nonspecific resistance are totally different. The present investigation of the effect on S. mansoni infection of Toxoplasma gondii, an intracellular protozoan parasite which renders mice resistant to a variety of unrelated organisms7–11, largely by activation of macrophages12, may clarify the role of nonspecific mechanisms in protection against schistosomiasis.
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MAHMOUD, A., WARREN, K. & STRICKLAND, G. Acquired resistance to infection with Schistosoma mansoni induced by Toxoplasma gondii. Nature 263, 56–57 (1976). https://doi.org/10.1038/263056a0
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DOI: https://doi.org/10.1038/263056a0
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