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Cloning of the T gene required in mesoderm formation in the mouse

Abstract

The murine developmental mutation T identifies an essential gene in mesoderm formation. Embryos lacking normal gene activity fail to form the notochord, the entire posterior region and the allan-tois, and die at about 10 days of gestation. We have isolated the T gene using a combination of molecular and genetic techniques, thus making molecular tools available to study processes underlying mesoderm formation in the mouse.

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Herrmann, B., Labeit, S., Poustka, A. et al. Cloning of the T gene required in mesoderm formation in the mouse. Nature 343, 617–622 (1990). https://doi.org/10.1038/343617a0

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