Abstract
Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8− thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-α is irrelevant in these developmental processes. The development of γδ T cells does not depend on either TCR-α or TCP-β.
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Mombaerts, P., Clarke, A., Rudnicki, M. et al. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360, 225–231 (1992). https://doi.org/10.1038/360225a0
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DOI: https://doi.org/10.1038/360225a0
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