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FOXP3+ regulatory T cells and their functional regulation

Cellular & Molecular Immunology volume 12, pages 558–565 (2015)Cite this article

Abstract

FOXP3+ regulatory T (Treg) cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years. Here, we summarize these intriguing findings, and provide insight into their potential use or manipulation during Treg cell therapy for the treatment of autoimmune diseases, graft-versus-host disease (GVHD) and cancer.

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Acknowledgements

This work is supported by National Basic Research Program of China (973 Program) 2014CB541803, 2014CB541903, NSFC 81330072, 31370863, 31170825, 81271835, 31200646, 81302532, 31350110505 and SMCST 11ZR1404900. We gratefully acknowledge the Chinese Academy of Sciences Fellowships for Young International Scientists (2013Y1SB0005) and the Knowledge Innovation Program of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (2012KIP204).

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  1. Dr. B Li, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China. E-mail: binli@sibs.ac.cn

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  1. Unit of Molecular Immunology, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

    Zhiyuan Li, Dan Li, Andy Tsun & Bin Li

  2. Innovent Biologics Inc., Suzhou, China

    Andy Tsun

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Li, Z., Li, D., Tsun, A. et al. FOXP3+ regulatory T cells and their functional regulation. Cell Mol Immunol 12, 558–565 (2015). https://doi.org/10.1038/cmi.2015.10

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