ArticleProgrammed death ligand-1 expression in non-small cell lung cancer
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NSCLC
PD-L1
survival
tumor-infiltrating lymphocytes
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Supplementary Information accompanies the paper on the Laboratory Investigation website
Programmed death ligand-1 (PDL1) is a key mechanism of immune evasion in human cancers, and PD-L1 expression on cancer cells may predict response to anti-PD1 therapy. This paper describes a reproducible method of measuring PD-L1 protein and mRNA in formalin-fixed paraffin-embedded samples and demonstrates the prognostic relevance of these biomarkers in non-small cell lung cancer.
Supplementary information The online version of this article (doi:10.1038/labinvest.2013.130) contains supplementary material, which is available to authorized users.
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Vamsidhar Velcheti and Kurt A Schalper: These authors contributed equally to this work.
© 2014 United States & Canadian Academy of Pathology.