Chromogenic stains have long been used in immunodiagnostic assays, but fluorescence-based readouts could supplant them as emphasis shifts away from diagnosis to prediction by means of quantifiable results.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Analysis of Immune Checkpoint Drug Targets and Tumor Proteotypes in Non-Small Cell Lung Cancer
Scientific Reports Open Access 17 June 2020
-
Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium
Reproductive Biology and Endocrinology Open Access 16 April 2020
-
Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2
Laboratory Investigation Open Access 22 October 2019
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
McCormick, D., Yu, C., Hobbs, C. & Hall, P.A. Histopathology 22, 543–547 (1993).
Hall, P.A. & Lane, D.P. J. Pathol. 172, 1–4 (1994).
McGuire, W.L. Annu. Rev. Med. 26, 353–363 (1975).
Garola, R.E. & McGuire, W.L. Cancer Res. 38, 2216–2220 (1978).
Pertschuk, L.P. et al. Cancer 46, 2896–2901 (1980).
Bezwoda, W.R., Esser, J.D., Dansey, R., Kessel, I. & Lange, M. Cancer 68, 867–872 (1991).
Harvey, J.M., Clark, G.M., Osborne, C.K. & Allred, D.C. J. Clin. Oncol. 17, 1474–1481 (1999).
Collins, L.C., Botero, M.L. & Schnitt, S.J. Am. J. Clin. Pathol. 123, 16–20 (2005).
Schnitt, S.J. J. Clin. Oncol. 24, 1797–1799 (2006).
Pauletti, G., Godolphin, W., Press, M.F. & Slamon, D.J. Oncogene 13, 63–72 (1996).
Press, M.F. et al. J. Clin. Oncol. 20, 3095–3105 (2002).
Press, M.F. et al. Clin. Cancer Res. 11, 6598–6607 (2005).
Mass, R.D. et al. Clin. Breast Cancer 6, 240–246 (2005).
Hasui, K. et al. J. Histochem. Cytochem. 51, 1169–1176 (2003).
Levenson, R.M. Cytometry (in the press).
McCabe, A., Dolled-Filhart, M., Camp, R.L. & Rimm, D.L. J. Natl. Cancer Inst. 97, 1808–1815 (2005).
Camp, R.L., Chung, G.G. & Rimm, D.L. Nat. Med. 8, 1323–1327 (2002).
van de Vijver, M.J. et al. N. Engl. J. Med. 347, 1999–2009 (2002).
Paik, S. et al. N. Engl. J. Med. 351, 2817–2826 (2004).
Yoon, S.O., Shin, S. & Lipscomb, E.A. Cancer Res. 66, 2732–2739 (2006).
Makretsov, N.A. et al. Clin. Cancer Res. 10, 6143–6151 (2004).
Alonso, S.R. et al. Am. J. Pathol. 164, 193–203 (2004).
Acknowledgements
Thanks to M. Dolled-Filhart, C. Kleer and C. Allred for critical review of this manuscript. Work in the Rimm laboratory is supported by grants R01 CA 114277, R33 CA 106709, R33 CA 110511 and an Avon Patients for Progress Grant from the U.S. National Institutes of Health and the Breast Cancer Alliance of Greenwich, Connecticut, USA. Dr. Rimm is a founder, stockholder and consultant to HistoRx, the exclusive licensee of the Yale owned AQUA patent.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rimm, D. What brown cannot do for you. Nat Biotechnol 24, 914–916 (2006). https://doi.org/10.1038/nbt0806-914
Issue Date:
DOI: https://doi.org/10.1038/nbt0806-914
This article is cited by
-
Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium
Reproductive Biology and Endocrinology (2020)
-
Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2
Laboratory Investigation (2020)
-
Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sorting
Nature Biomedical Engineering (2020)
-
Analysis of Immune Checkpoint Drug Targets and Tumor Proteotypes in Non-Small Cell Lung Cancer
Scientific Reports (2020)
-
Highly Multiplexed, Quantitative Tissue Imaging at Cellular Resolution
Current Pathobiology Reports (2019)