Clear cell renal cell carcinoma (CCRCC) is characterized by mutation of the VHL gene and loss of a segment of chromosome 3. A new study using multi-region exome sequencing has identified substantial intratumoral heterogeneity within large primary CCRCCs, which has profound implications for understanding tumor evolution and for developing effective therapies.
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Ricketts, C., Linehan, W. Intratumoral heterogeneity in kidney cancer. Nat Genet 46, 214–215 (2014). https://doi.org/10.1038/ng.2904
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DOI: https://doi.org/10.1038/ng.2904
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