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Noncoding RNA and its associated proteins as regulatory elements of the immune system

Nature Immunology volume 15, pages 484–491 (2014)Cite this article

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Abstract

The rapid changes in gene expression that accompany developmental transitions, stress responses and proliferation are controlled by signal-mediated coordination of transcriptional and post-transcriptional mechanisms. In recent years, understanding of the mechanics of these processes and the contexts in which they are employed during hematopoiesis and immune challenge has increased. An important aspect of this progress is recognition of the importance of RNA-binding proteins and noncoding RNAs. These have roles in the development and function of the immune system and in pathogen life cycles, and they represent an important aspect of intracellular immunity.

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Figure 1: Contribution of untranslated and coding sequence to the length of human interleukin mRNAs.
Figure 2: Diverse lncRNA mechanisms.
Figure 3: Processing in the nucleus regulates mRNA fate.
Figure 4: RNA and RBP interact to regulate gene expression.

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Acknowledgements

We thank M. Linterman, P. Katsikis, R. Newman and L. Webb for advice and comments on the manuscript. Supported by the Biotechnology and Biological Sciences Research Council, the Medical Research Council (M.T. and E.V.) and Leukaemia and Lymphoma Research (A.G.).

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  1. Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, Cambridge, UK

    Martin Turner, Alison Galloway & Elena Vigorito

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Turner, M., Galloway, A. & Vigorito, E. Noncoding RNA and its associated proteins as regulatory elements of the immune system. Nat Immunol 15, 484–491 (2014). https://doi.org/10.1038/ni.2887

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