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Spotlight on Chronic Lymphocytic Leukemia

The configuration of the immunoglobulin genes in B cell chronic lymphocytic leukemia

Abstract

B cell chronic lymphocytic leukemia (CLL) lacks a consistent genetic abnormality. However, immunoglobulin VH gene segment mutation analysis has provided insights into the pathogenesis of these diseases and allowed the development of powerful prognostic markers. Immunoglobulin gene chromosomal translocations are rare in CLL and involve a distinct subset of genes including BCL3, BCL11A and CCND2. BCL2 translocations in CLL appear to arise via a different mechanism from comparable translocations seen in B cell non-Hodgkin lymphoma.

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Acknowledgements

We thank our colleagues in Bournemouth, Southampton, Sutton and Leicester for their help in the preparation of this manuscript. We thank Drs Reiner Siebert (Institute for Human Genetics, University of Kiel, Germany) for permission to quote unpublished data. We thank Dr Wal Zani (Amgen, UK) for his help in the preparation of Figure 2.

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Dyer, M., Oscier, D. The configuration of the immunoglobulin genes in B cell chronic lymphocytic leukemia. Leukemia 16, 973–984 (2002). https://doi.org/10.1038/sj.leu.2402528

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