Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia

Leukemia volume 19, pages 883–885 (2005)Cite this article

TO THE EDITOR

Correct classification of leukemia and lymphoma forms is essential for the selection of effective therapies. Traditionally, classification relied on cytology, but, increasingly, molecular characteristics of tumor cells are being utilized for diagnosis. Also, measurement of soluble products released by tumor cells provides a comparatively easy and reliable method to monitor tumor progression and/or efficacy of therapy.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Michel J, Langstein J, Hofstädter F, Schwarz H . A soluble form of CD137 (ILA/4-1BB) is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis. Eur J Immunol 1998; 28: 290–295.

    Article  CAS  Google Scholar 

  2. Michel J, Schwarz H . Soluble CD137 is selectively expressed by T lymphocytes and correlates with activation induced cell death of lymphocytes. Cytokine 2000; 12: 742–746.

    Article  CAS  Google Scholar 

  3. DeBenedette MA, Chu NR, Pollok KE, Hurtado J, Wade WF, Kwon BS et al. Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP. J Exp Med 1995; 181: 985–992.

    Article  CAS  Google Scholar 

  4. Hurtado JC, Kim SH, Pollok KE, Lee ZH, Kwon BS . Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28. J Immunol 1995; 155: 3360–3367.

    CAS  PubMed  Google Scholar 

  5. Sharief MK . Heightened intrathecal release of soluble CD137 in patients with multiple sclerosis. Eur J Neurol 2002; 9: 49–54.

    Article  CAS  Google Scholar 

  6. Jung HW, Choi SW, Choi JI, Kwon BS . Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis. Exp Mol Med 2004; 36: 13–22.

    Article  CAS  Google Scholar 

  7. Martinsson U, Sundstrom C, Glimelius B . Immunophenotype analysis of B-CLL lymphoma and immunocytoma. APMIS 1989; 97: 1025–1032.

    Article  CAS  Google Scholar 

  8. Stein H . Classification of non-Hodgkin's lymphomas on the basis of Morphological and immunological features shared by normal and neoplastic lymphatic cells. Immun Infekt 1976; 4: 52–69.

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by the German Cancer Research Foundation (Deutsche Krebshilfe).

Author information

Authors and Affiliations

  1. Department of Pathology, University of Regensburg, Regensburg, Germany

    M Furtner & H Schwarz

  2. Department of Internal Medicine I, University of Regensburg, Regensburg, Germany

    R H Straub

  3. Department of Hematology, University of Regensburg, Regensburg, Germany

    S Krüger

  4. Department of Physiology, National University of Singapore, Singapore

    H Schwarz

Authors
  1. M Furtner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R H Straub
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S Krüger
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H Schwarz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to H Schwarz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Furtner, M., Straub, R., Krüger, S. et al. Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia. Leukemia 19, 883–885 (2005). https://doi.org/10.1038/sj.leu.2403675

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403675

This article is cited by

Search

Advanced search

Quick links