Original InvestigationPathogenesis and Treatment of Kidney DiseaseBleeding Complications of Native Kidney Biopsy: A Systematic Review and Meta-analysis
Section snippets
Data Sources and Searches
We conducted a PubMed search of English-language studies published from January 1, 1980, through June 27, 2011. The MeSH (medical subject heading) terms and subheadings used were kidney, biopsy/needle, biopsy/fine needle, biopsy/adverse effects, and biopsy/complication. Each MeSH term was used in combination with the text words “biopsy” and “kidney.” Additional studies were identified through a manual search of the bibliographies in retrieved studies.
Study Selection
One author (K.M.C.) performed the literature
Description of Included Studies
The initial search yielded 2,472 studies (Fig 1). Of these, 2,173 were deemed ineligible because they were not related to the study question. We reviewed the full text of the remaining 299 studies for possible inclusion and excluded 265 studies based on selection criteria. Thirty-four publications were included for analysis (Table 1).15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48 Thirty studies provided data
Discussion
This study presents what to our knowledge is the first systematic review and meta-analysis of hemorrhagic complications after percutaneous native kidney biopsy using ultrasonographic guidance and an automated spring-loaded biopsy device. We confirmed that the rate of major and minor complications is relatively low when native kidney biopsies are performed using the current technique. Both macroscopic hematuria and need for erythrocyte transfusion are important complications of kidney biopsy
Acknowledgements
Support: None.
Financial Disclosure: The authors declare that they have no relevant financial interests.
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Originally published online April 26, 2012.