Infiltration by immunocompetent cells in early stage invasive carcinoma of the uterine cervix: a prognostic study
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2020, Pathology Research and PracticeCitation Excerpt :Most studies to date have focused on the assessment of TILs within the primary tumor while largely ignoring peritumoral patterns of immune infiltrates. Consistent with earlier studies [28–34], our current data, therefore, highlight the prognostic utility of TILs infiltrating the primary tumor or peritumor. Macrophages are critical immune effector cells and one of the major components of tumor-infiltrating leukocytes.
Gyneco-oncological genomics and emerging biomarkers for cancer treatment with immune-checkpoint inhibitors
2018, Seminars in Cancer BiologyCitation Excerpt :The detection of significant numbers of tumor-infiltrating lymphocytes [TIL] in cervical carcinoma tissues underlines the importance of cell mediated immune response in this malignancy [24]. Bethwaite et al. found an association among low density of TIL, risk of pelvic lymph node involvement, and subsequent local or distant failure (p = 0.008) in women with early-stage cervical cancer [24]. Overall survival was significantly better for patients with >5 CD3 + TIL per high power field [HPF] compared with those with lower CD3 + TIL count.
Immunotherapy
2017, Oral, Head and Neck Oncology and Reconstructive Surgery