1887

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Volume 89, Issue 11

Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection Free

Abstract

The vaccinia virus (VACV) N1 protein is an intracellular virulence factor that has a Bcl-2-like structure and inhibits both apoptosis and signalling from the interleukin 1 receptor, leading to nuclear factor kappa B activation. Here, we investigated the immune response to intranasal infection with a virus lacking the gene (vΔN1L) compared with control viruses expressing . Data presented show that deletion of did not affect the proportion of CD4 and CD8 T cells infiltrating the lungs or the cytotoxic T-cell activity of these cells. However, vΔN1L induced an increased local natural killer cell activity between days 4 and 6 post-infection. In addition, in the absence of N1 the host inflammatory infiltrate was characterized by a reduced proportion of lymphocytes bearing the early activation marker CD69. Notably, there was a good correlation between the level of CD69 expression and weight loss. The implications of these findings are discussed.

  • Received:
  • Accepted:
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2008-11-01
2024-04-19
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Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection
J. Gen. Virol. 89, 2877 (2008); https://doi.org/10.1099/vir.0.2008/004119-0
/content/journal/jgv/10.1099/vir.0.2008/004119-0
/content/journal/jgv/10.1099/vir.0.2008/004119-0
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