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Annual Review of Immunology

Volume 36, 2018

Signaling and Function of Interleukin-2 in T Lymphocytes

Abstract

The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling pathways that allow IL-2 to control the differentiation and homeostasis of both pro- and anti-inflammatory T cells is fundamental to determining the molecular details of immune regulation. The IL-2 receptor couples to JAK tyrosine kinases and activates the STAT5 transcription factors. However, IL-2 does much more than control transcriptional programs; it is a key regulator of T cell metabolic programs. The development of global phosphoproteomic approaches has expanded the understanding of IL-2 signaling further, revealing the diversity of phosphoproteins that may be influenced by IL-2 in T cells. However, it is increasingly clear that within each T cell subset, IL-2 will signal within a framework of other signal transduction networks that together will shape the transcriptional and metabolic programs that determine T cell fate.

Keyword(s): cytokine signaling, interleukin-2, JAK1/3, PI3K
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/content/journals/10.1146/annurev-immunol-042617-053352
2018-04-26
2024-04-19
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/content/journals/10.1146/annurev-immunol-042617-053352
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Signaling and Function of Interleukin-2 in T Lymphocytes
Annual Review of Immunology 36, 411 (2018); https://doi.org/10.1146/annurev-immunol-042617-053352
/content/journals/10.1146/annurev-immunol-042617-053352
/content/journals/10.1146/annurev-immunol-042617-053352
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