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Clinical Significance of Melanoma Antigen-Encoding Gene-1 (MAGE-1) Expression and its Correlation with Poor Prognosis in Differentiated Advanced Gastric Cancer

  • Translational Research and Biomarkers
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Abstract

Background

Melanoma antigen-encoding gene-1 (MAGE-1), a cancer/testis antigen, has been reported to be expressed in various types of cancer. We investigated the clinicopathological features and prognostic significance of MAGE-1 expression in advanced gastric cancer (AGC).

Methods

Immunohistochemical staining for MAGE-1 was performed on surgical specimens obtained from 135 patients with AGC.

Results

Positive expression of MAGE-1 detected in cytoplasm was observed in 44 of 135 cases (32.6%) in primary tumors and 26 of 96 (27.1%) in lymph node metastases. In noncancerous gastric tissues, apparent MAGE-1 expression was not detected. MAGE-1 in primary tumor was correlated with advanced age (P < 0.001), macroscopic infiltrated type (P = 0.035), and presence of vascular invasion (P = 0.027). The 5-year cancer-specific survival rates of AGC patients with positive MAGE-1 expression were significantly lower than those of patients with negative MAGE-1 (positive: 31.6%, negative: 57.6%, P = 0.038). On multivariate analysis, MAGE-1 expression was not an independent prognostic predictor of AGC (P = 0.064). In differentiated AGC patients, MAGE-1 expression was correlated with advanced age (P = 0.003), macroscopic infiltrated type (P = 0.009), and presence of lymph node metastasis (P = 0.033). The cancer-specific survival rates of differentiated AGC patients with positive MAGE-1 were significantly lower than those of patients with negative MAGE-1 (P = 0.003). Positive MAGE-1 expression was an independent prognostic factor of differentiated AGC patients on multivariate analysis (P = 0.031).

Conclusions

These findings suggest that MAGE-1 protein expression can serve as a predictive marker of poor prognosis in differentiated AGC patients.

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Acknowledgement

The authors would like to thank M. Sakai, T. Kobayashi, E. Yamaki, and K. Araki for helpful discussions. We are also grateful to R. Aoyagi for excellent technical assistance.

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Authors and Affiliations

  1. Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Kyoichi Ogata MD, Erito Mochiki MD, PhD, Atsushi Ogawa MD, Mitsuhiro Yanai MD, Yoshitaka Toyomasu MD, PhD, Hiroyuki Ando MD, PhD, Tetsuro Ohno MD, PhD, Takayuki Asao MD, PhD & Hiroyuki Kuwano MD, PhD

  2. Department of Surgery, Saiseikai Maebashi Hospital, Maebashi, Gunma, Japan

    Ryuusuke Aihara MD, PhD

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  1. Kyoichi Ogata MD
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  2. Ryuusuke Aihara MD, PhD
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Correspondence to Kyoichi Ogata MD.

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Ogata, K., Aihara, R., Mochiki, E. et al. Clinical Significance of Melanoma Antigen-Encoding Gene-1 (MAGE-1) Expression and its Correlation with Poor Prognosis in Differentiated Advanced Gastric Cancer. Ann Surg Oncol 18, 1195–1203 (2011). https://doi.org/10.1245/s10434-010-1399-z

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  • DOI: https://doi.org/10.1245/s10434-010-1399-z

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