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Multifactorial Analysis of Prognostic Factors and Survival Rates Among 706 Mucosal Melanoma Patients

  • Melanomas
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The hypothesis that mucosal melanomas from different anatomic sites would have different prognostic features and survival outcome was tested in a multifactorial analysis.

Methods

Complete clinical and pathological information from 706 mucosal melanoma patients from different anatomical sites was compared for overall survival (OS) and prognostic factors.

Results

Mucosal melanomas arising from different anatomical sites did not have any significant differences in OS in a multivariate analysis (p = 0.721). Among all 706 stage I–IV mucosal melanoma patients, depth of tumor invasion (p < 0.001), number of lymph node metastases (p < 0.001), and sites of distant metastases (p < 0.001) were independent prognostic factors for OS; among 543 stage I–III patients, depth of tumor invasion (p < 0.001) and number of lymph node metastases (p < 0.001) were independent prognostic factors for OS; and among 547 stage IV patients, depth of tumor invasion (p = 0.009), number of lymph node metastases (p < 0.001), and combined distant metastases and elevation of serum lactate dehydrogenase (LDH; p < 0.001) were independent prognostic factors for OS. The presence of c-KIT or BRAF mutations was not predictive of survival.

Conclusions

This is the first large-scale study comparing outcomes of mucosal melanomas from different anatomic sites in a multifactorial analysis. There were no significant survival differences among mucosal melanomas arising at different sites when matched for staging and prognostic and molecular factors, thus rejecting our hypothesis. We concluded that prognostic characteristics of mucosal melanomas can be staged as a single histological group, regardless of the anatomic site of the primary tumor.

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Acknowledgments

The authors wish to thank the patients and their families for making this study possible.

Funding

This work was supported by grants from Beijing Talents Fund (2016000021469G186, 2016000021223ZK18, 2014000021223ZK26), Beijing Municipal Administration of Hospitals Incubating Program (PX2017042), National Natural Science Foundation of China (81672696), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201603), and Beijing Municipal Science and Technology Commission (Z151100003915074).

Author information

Author notes

  1. ChuanLiang Cui and Bin Lian have contributed equally to this work and are the co-first authors.

Authors and Affiliations

  1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing, China

    ChuanLiang Cui MD, Bin Lian MD, Li Zhou MD, ZhiHong Chi MD, Lu Si MD, XiNan Sheng MD, Yan Kong PhD, BiXia Tang MD, LiLi Mao MD, Xuan Wang MD, SiMing Li MD, Jie Dai PhD, XieQiao Yan MD, Xue Bai MD & Jun Guo MD, PhD

  2. Yunnan Cancer Hospital, Kunming, China

    Xin Song MD

  3. SUN YAT-SEN University Cancer Center, Guangzhou, China

    XiaoShi Zhang MD

  4. The First Hospital of Jilin University, Changchun, China

    Di Wu MD

  5. University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Charles M. Balch MD

Authors
  1. ChuanLiang Cui MD
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  2. Bin Lian MD
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  3. Li Zhou MD
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  4. Xin Song MD
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  5. XiaoShi Zhang MD
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  6. Di Wu MD
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  7. ZhiHong Chi MD
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  8. Lu Si MD
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  9. XiNan Sheng MD
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  10. Yan Kong PhD
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  11. BiXia Tang MD
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  12. LiLi Mao MD
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  13. Xuan Wang MD
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  14. SiMing Li MD
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  15. Jie Dai PhD
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  16. XieQiao Yan MD
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  17. Xue Bai MD
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  18. Charles M. Balch MD
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  19. Jun Guo MD, PhD
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Contributions

Conception and design: JG, CMB, CLC, BL. Provision of study materials or patients: CLC, BL, LZ, XS, XSZ, DW. Collection and assembly of data: JG, CLC, BL, LZ, XS, XSZ, DW, ZHC, LS, XNS, YK, BXT, LLM, XW, SML, JD, XQY, XB. Data analysis and interpretation: JG, CMB, CLC, BL, LZ. Manuscript writing: All authors. Final approval of the manuscript submitted for publication: All authors.

Corresponding authors

Correspondence to Charles M. Balch MD or Jun Guo MD, PhD.

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Disclosures

ChuanLiang Cui, Bin Lian, Li Zhou, Xin Song, XiaoShi Zhang, Di Wu, ZhiHong Chi, Lu Si, XiNan Sheng, Yan Kong, BiXia Tang, LiLi Mao, Xuan Wang, SiMing Li, Jie Dai, XieQiao Yan, Xue Bai, Charles M. Balch, and Jun Guo have declared no conflicts of interest.

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Cui, C., Lian, B., Zhou, L. et al. Multifactorial Analysis of Prognostic Factors and Survival Rates Among 706 Mucosal Melanoma Patients. Ann Surg Oncol 25, 2184–2192 (2018). https://doi.org/10.1245/s10434-018-6503-9

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  • DOI: https://doi.org/10.1245/s10434-018-6503-9

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