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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

PDGF-D Signaling: A Novel Target in Cancer Therapy

Author(s): Zhiwei Wang, Dejuan Kong, Yiwei Li and Fazlul H. Sarkar

Volume 10, Issue 1, 2009

Page: [38 - 41] Pages: 4

DOI: 10.2174/138945009787122914

Price: $65

Abstract

Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation, transformation, invasion, and angiogenesis by specifically binding to and activating its cognate receptor PDGFR-β. The functions of PDGF-D in human cancer progression are largely unknown. We discuss here the role of PDGF-D signaling pathway in cancer and how its deregulation is involved in tumor development and progression to metastatic disease.

Keywords: PDGF-D, cancer, EMT, signaling, therapy, invasion, stem cells, nutrition


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